摘要：藜芦醛不仅可以作为一种重要的合成香料来使用，且GB2760-1996将其规定为允许食用的香料，同时在有机合成中间体和医药合成中间体中，藜芦醛也占据着不可小觑的作用。在医药工业方面，藜芦醛可以合成甲基多巴等药物。

本设计是对年产1000吨藜芦醛进行工艺设计研究，藜芦醛的生产是以邻苯二酚、乙醛酸等为原料，经缩合、氧化脱羧、甲基化等三步反应得藜芦醛粗品，再经精制得藜芦醛成品。设计内容主要是根据已有的工艺路线进行物料衡算，在物料衡算计算结果的基础上再进行能量衡算，并且对工序中涉及到的主要设备进行选型，车间平面布置，以及查阅相关资料撰写、行政法规执行措施.最后，对本次设计过程中优缺点进行总结。并且绘制了工艺管道及仪表流程图、车间平面布置图等设计图纸。

关键词: 藜芦醛；工艺设计；物料衡算；能量衡算；设备选型

Study on the Process Design of 1000 tons of 3,4-DIMETHOXYBENZENECARBONAL

Abstract: 3,4-DIMETHOXYBENZENECARBONAL can be used not only as an important synthetic fragrance, but also as a permissible spice in GB2760-1996. In the intermediates of organic synthesis and intermediates for pharmaceutical synthesis, 3,4-DIMETHOXYBENZENECARBONAL is also important. The role. In the pharmaceutical industry, 3,4-DIMETHOXYBENZENECARBONAL can be used to synthesize drugs such as methyldopa.

This design is to carry out technological design research on the annual production of 1,000 tons of 3,4-DIMETHOXYBENZENECARBONAL,it is based on catechol, glyoxylic acid and other raw materials, through condensation, oxidative decarboxylation, methylation and other three-step reaction to get verarum aldehyde crude products, and then refined rhodium aldehyde product. The design content is mainly based on the existing process route for material balance calculation, based on the calculation results of the material balance, and then the energy balance, and the selection of the main equipment involved in the process, the layout of the workshop, and consult related Data writing and administrative regulations implementation measures. Finally, we summarize the advantages and disadvantages of this design process. And draw the process piping and instrument flow chart, workshop floor plan and other design drawings

Key words: 3,4-DIMETHOXYBENZENECARBONAL process design; material balance; energy balance; equipment selection

目录

1.绪论 7

1.1 香料及藜芦醛 7

1.1.1 香料概况 7

1.1.2香料的发展历史 7

1.1.3芳香族醛类香料概述 7

1.1.4藜芦醛的性质 8

1.1.5藜芦醛研发前景 8

1.2.合成藜芦醛的路线 8

1.2.1合成路线一 8

1.2.2合成路线二 9

1.2.3合成路线三 9

1.2.4总结 9

2藜芦醛的应用 10

2.1盐酸哌唑嗪的合成 10

2.2利喘贝的合成 10

3.藜芦醛的生产工艺流程 10

3.1设计依据及基础资料 10

3.2基本原理 11

3.3设计生产工艺流程和设备操作要点 12

3.3.1缩合工序 12

3.3.2氧化-脱羧工序 12

3.3.3甲基化工序 12

3.4操作要点 12

3.4.1 n(氢氧化钠)：n(3，4－二羟基苯甲醛)对收率的影响 12

3.4.2　n(硫酸二甲酯)∶n(3，4－二羟基苯甲醛)对收率的影响 12

4．主要原材料的物性数据 13

4.1主要原材料的物性数据 13

5藜芦醛的物料衡算及能量衡算 14

5.1藜芦醛的物料衡算 14

5.1.1物料衡算基础 14

5.1.2初始投料计算 14

5.1.3缩合工序物料衡算 15

5.1.4 氧化脱羧工序物料衡算 18

5.1.5 甲基化工序物料衡算 22

5.2能量恒算 25

5.2.1 能量衡算基础 25

5.2.2 缩合工序能量衡算 26

5.2.3氧化脱羧工序能量衡算 29

5.2.4甲基化工序能量衡算 33

6主要设备选型及计算 36

6.1设备选型原则 36