[144] A.G. Mensah-Nyagan, J.L. Do-Rego, D. Beaujean, V. Luu-The, G. Pelletier, H. Vaudry, Regulation of neurosteroid biosynthesis in the frog diencephalon by GABA and endozepines, Horm. Behav. 40 (2001) 218–225.

[145] H. Vaudry, J.L. Do Rego, D. Burel, V. Luu-The, G. Pelletier, D. Vaudry, K. Tsutsui, Neurosteroid biosynthesis in the brain of amphibians, Front. Endocrinol. 2 (2011) 79.

[146] J. Iwabuchi, S. Wako, T. Tanaka, A. Ishikawa, Y. Yoshida, S. Miyata, Analysis of the p450 aromatase gene expression in the Xenopus brain and gonad, J. Steroid Biochem. Mol. Biol. 107 (2007) 149–155.

[147] S. Kuntz, A. Chesnel, S. Flament, D. Chardard, Cerebral and gonadal aromatase expressions are differently affected during sex differentiation of Pleurodeles waltl, J. Mol. Endocrinol. 33 (2004) 717–727.

[148] V.S. Langlois, A.C. Carew, B.D. Pauli, M.G. Wade, G.M. Cooke, V.L. Trudeau, Low levels of the herbicide atrazine alter sex ratios and reduce metamorphic success in Rana pipiens tadpoles raised in outdoor mesocosms, Environ. Health Perspect. 118 (2010) 552–557.

[149] V.S. Langlois, P. Duarte-Guterman, V.L. Trudeau, Expression profiles of reproductionand thyroid hormone-related transcripts in the brains of chemically-induced intersex frogs, Sex. Dev. 5 (2011) 26–32.

[150] R. Urbatzka, I. Lutz, W. Kloas, Aromatase, steroid-5-alpha-reductase type 1 and type 2mRNA expression in gonads and in brain of Xenopus laevis during ontogeny, Gen. Comp. Endocrinol. 153 (2007) 280–288.

[151] S. Kuntz, D. Chardard, A. Chesnel, M. Ducatez, M. Callier, S. Flament, Expression of aromatase and steroidogenic factor 1 in the lung of the urodele amphibian Pleurodeles waltl, Endocrinology 145 (2004) 3111–3114.

[152] P. Coumailleau, O. Kah, Cyp19a1 (aromatase) expression in the Xenopus brain at different developmental stages, J. Neuroendocrinol. 26 (2014) 226–236.

[153] L. Burrone, A. Santillo, C. Pinelli, G.C. Baccari, M.M. Di Fiore, Induced synthesis of P450 aromatase and 17beta-estradiol by D-aspartate in frog brain, J. Exp. Biol. 215 (2012) 3559–3565.

[154] T.Nakagawa, J. Iwabuchi,Brain-specific promoter/exon I.f of the cyp19a1 (aromatase) gene in Xenopus laevis, J. Steroid Biochem.Mol. Biol. 132 (2012) 247–255.

[155] S.Miyata, T. Kubo, In vitro effects of estradiol and aromatase inhibitor treatment on sex differentiation in Xenopus laevis gonads, Gen. Comp. Endocrinol. 119 (2000) 105–110.

[156] G. Okada, K. Maruo, S. Funada, M. Nakamura, Differential display analysis of gene expression in female-to-male sex-reversing gonads of the frog Rana rugosa, Gen. Comp. Endocrinol. 155 (2008) 623–634.

[157] I. Villalpando, H. Merchant-Larios, Determination of the sensitive stages for gonadal sex-reversal in Xenopus laevis tadpoles, Int. J. Dev. Biol. 34 (1990) 281–285.

[158] T.B. Hayes, Sex determination and primary sex differentiation in amphibians: genetic and developmental mechanisms, J. Exp. Zool. 281 (1998) 373–399.

[159] C.A. Mackenzie, M. Berrill, C. Metcalfe, B.D. Pauli, Gonadal differentiation in frogs exposed to estrogenic and antiestrogenic compounds, Environ. Toxicol. Chem. 22 (2003) 2466–2475.

[160] W. Kloas, Amphibians as a model for the study of endocrine disruptors, Int. Rev. Cytol. 216 (2002) 1–57.

[161] N.S. Hogan, P. Duarte, M.G. Wade, D.R. Lean, V.L. Trudeau, Estrogenic exposure affects metamorphosis and alters sex ratios in the northern leopard frog (Rana pipiens): identifying critically vulnerable periods of development, Gen. Comp. Endocrinol. 156 (2008) 515–523.

[162] L. Szymanski, J. Bakker, Aromatase knockout mice show normal steroid-induced activation of gonadotrophin-releasing hormone neurones and luteinising hormone surges with a reduced population of kisspeptinneurones in the rostral hypothalamus, J. Neuroendocrinol. 24 (2012) 1222–1233.

[163] W. Kloas, R. Urbatzka, R. Opitz, S.Wurtz, T. Behrends, B. Hermelink, F. Hofmann, O. Jagnytsch, H. Kroupova, C. Lorenz, N. Neumann, C. Pietsch, A. Trubiroha, C. Van Ballegooy, C. Wiedemann, I. Lutz, Endocrine disruption in aquatic vertebrates, Ann. N. Y. Acad. Sci. 1163 (2009) 187–200.