摘要：就现阶段来说该产品是一个重要药物的关键中间体，该重要药物是利塞膦酸钠。它算是用于治疗防范骨质疏松症病发的最重要实用的临床药品之一。另外，3-乙酰基吡啶可以用作一些食物的香味剂。作为现在主要临床药物，用于治疗骨质疏松症的双膦酸盐类的，这类药的疗效明显，具体的疗效依据患者而定。其中，利塞膦酸钠是新一代双膦酸盐类药物的明星代表。催化剂贵、反应的要求严格、反应时间久、试剂的危害性大，产品产率不高和环境不友好等问题是目前生产3-乙酰基吡啶工艺的集中突出需要解决的。

本设计为年产1000吨3-乙酰基吡啶的工设研究，综述了3-乙酰基吡啶与利塞膦酸钠的关系、治疗骨质疏松症药物的研究背景、并对其多条合成路线进行阐述与对比，最终选出一条最恰当的路线进行研究，进行了生产工艺的物料衡算、能量衡算，在此基础上对设备进行选型。并对车间布置进行说明，绘制出带管道及控制点的工艺流程图与车间布置图。

关键词：利塞膦酸钠；关键中间体；3 -乙酰吡啶；工艺设计；物料衡算；能量衡算；设备选型

The Process design of 1000t 3-Acetylpyridine per year

Abstract: At present, this product is a key intermediate of an important drug, which is risedronate sodium. It is one of the most important and practical clinical drugs used to treat and prevent osteoporosis. In addition, 3 - acetyl pyridine can be used as a flavoring agent for some foods. As the main clinical drug at present, bisphosphonates used for treating osteoporosis have obvious curative effect, and the specific curative effect depends on the patient. Among them, risedronate sodium is the star representative of new bisphosphonate drugs. Problems such as expensive catalyst, strict reaction requirements, long reaction time, great harmfulness of reagents, low yield of products and environmental friendliness are the concentrated and outstanding problems to be solved in the current process of producing 3 - acetyl pyridine.

        This design is a research project with an annual output of 1,000 tons of 3 - acetyl pyridine. it summarizes the relationship between 3 - acetyl pyridine and risedronate sodium, the research background of drugs for treating osteoporosis, and elaborates and compares several synthetic routes. finally, it selects one of the most appropriate routes to conduct research, calculates the material balance and energy balance of the production process, and on this basis, it selects the equipment. And the workshop layout is explained, and the process flow chart and workshop layout chart of belt tracks and control points are drawn.

Keywords: Risedronate sodium; Key intermediate; 3 - acetylpyridine; Process design; Material balance; Energy balance; Equipment selection 

目录

1 绪论 1

1.1 3-乙酰基吡啶的价值 1

1.1.1 利塞膦酸钠的社会地位 1

1.1.2 骨质疏松症及其发展史 1

1.2 3-乙酰基吡啶的合成路线综述 2

1.3 方案结论 4

2 3-乙酰基吡啶的缩合剂及3-乙酰基吡啶简介 6

2.1 醇钠缩合剂 6

2.3 3-乙酰基吡啶简介： 6

3 3-乙酰基吡啶设计基本原理及生产工艺流程 7

3.1设计依据及基础资料 7

3.2基本原理 7

3.3 设计生产工艺流程 8

3.3.1 酯化工序 8

3.3.2 Claisen缩合工序 8

3.3.3 水解脱羧工序 8

3.3.4 精制工序 8

3.4 工艺流程框图 9

3.5 生产操作注意点 10

4 主要原材料物性参数 11

4.1主要原材料物性参数 11

5 3-乙酰基吡啶的物料衡算 13

5.1 3-乙酰基吡啶的物料衡算 13

5.2 各工序过程中的物料衡算 14

5.2.1 酯化工序 14

5.2.2 缩合工序 20

5.2.3 水解脱羧工序 21

5.2.3 精制工序 26

6 能量衡算 27

6.1 能量衡算依据 27