（2） 卤素置换法

卤素置换法与置换反应机理相似。第一步制取CX3取代的化合物（其中X是指卤素），接着使用HF氟化来最终得到三氟甲基化合物。

①四氯化碳-氟化氢法

四氯化碳-氟化氢法的主产物就是邻取代三氟甲基芳胺。此种方法就是使用芳胺或者芳胺衍生物，然后与超强酸HF-SbF5在四氯化碳中反应，待反应完成后，用氟化试剂完成卤素交换，最后就可以得到三氟甲基化产物[ ]。

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